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Moreover, the multidrug resistance protein-1 (MDR1, ABCB1), which transports organic cations, and the multidrug resistance protein-2 (MRP2, ABCC2), which regulates the independent flow of bile salts by excreting glutathione are involved [20]

This resulted in the selection of leucovorin and dyclonine, two FDA-approved compounds, which we demonstrated to have brain repair and pro-oligodendrogenic activities in both preterm birth brain injury and adult demyelination mouse models, with leucovorin demonstrating broader beneficial effects

Their main mechanisms include membrane disruption, wherein they interact with microbial membranes, integrating into the lipid bilayer and causing physical disruption, pore formation, or complete membrane disintegration

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